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Life Sciences
Grant Access To Your World
Life Sciences
Grant access to your world
Opportunities and tradeoffs in single-cell transcriptomics
Beyond gene expression I Single-cell profiling of antigen receptor variable sequences I Overview of single-cell RNA-seq approaches. Conte MI, et al. (2023) Trends in Genetics doi.org/10.1016/j.tig.2023.10.003
Lysosomal storage disease explained for young audience
The lysosome and its function – Healthy and dysfunctional lysosome presented as garbage collector and recycling center ; created for ‘Frontiers for Young Minds: Science for kids’ Stefanie Flunkert & Tatjana Hirschmugl (2023) Check out more information here!
Therapeutic intervention with epigenetic modifications
‘Writers’ add marks, ‘Erasers’ read marks and ‘Readers’ detect marks. Scheme created for CelerisTx
Biology Across Scales 2024
Advertising banner for the ‘Biology Across Scales’ Symposium organized by the Instituto Gulbenkian de Ciência, Portugal in 2024
Check out their website: Bioscales 2024
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches
Targeted protein degradation – A review on how proteomics and functional genomics can be integrated to identify and mechanistically understand degraders, their target selectivity as well as putative resistance mechanisms. Scholes NS, et al. (2021) Cell Chem. Biol. doi.org/10.1016/j.chembiol.2021.03.007
The nucleus acts as a ruler
Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This in turn activates signaling to the actomyosin cortex and enables cells to pass through restrictive pores in complex 3D environments. Lomakin A, et al. (2020) Science. doi: 10.1126/science.aba2894
Mockup template by www.freepik.com
Title: Polymerase δ deficiency
Text: Identification of novel syndrome with replicative stress, neurodevelopmental abnormalities, and immunodeficiency.
Ref: Conde CD and Petronczki ÖY, et al. (2019) J Clin Invest. doi: 10.1172/JCI128903
Text: Identification of novel syndrome with replicative stress, neurodevelopmental abnormalities, and immunodeficiency.
Ref: Conde CD and Petronczki ÖY, et al. (2019) J Clin Invest. doi: 10.1172/JCI128903
Polymerase δ deficiency
Identification of novel syndrome with replicative stress, neurodevelopmental abnormalities, and immunodeficiency. Conde CD and Petronczki ÖY, et al. (2019) J Clin Invest. doi: 10.1172/JCI128903
RhoG Deficiency causes HLH
RhoG deficiency causes HLH
RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis. Kalinichenko A et al. (2021) Blood https://doi.org/10.1182/blood.2020008738
Title: Culturing murine neurons
Text: Stepwise procedure of neuronal dissection from murine hippocampus
Ref: Vanja Nagy/LBI-RUD Vienna
Text: Stepwise procedure of neuronal dissection from murine hippocampus
Ref: Vanja Nagy/LBI-RUD Vienna
Culturing murine neurons
Stepwise procedure of neuronal dissection from murine hippocampus. Vanja Nagy/LBI-RUD Vienna
Genotypic impact on sugar beet storability
An integrative comparative transcriptomic approach on six sugar beet varieties showing different amount of sucrose loss during storage revealed genotype-specific main driver genes and pathways characterizing storability. Study design according to overview figure. Madritsch S et al. (2020) Plant Mol Biol. https://doi.org/10.1007/s11103-020-01041-8
Title: Fra-2 as a regulator of inflammation
Text:
Ref: Birnhuber A, et al. (2019) Cell Signal. doi: 10.1016/j.cellsig.2019.109408
Text:
Ref: Birnhuber A, et al. (2019) Cell Signal. doi: 10.1016/j.cellsig.2019.109408
Fra-2 as a regulator of inflammation
Elevated expression of Fra-2 has been described in chronic lung diseases. In mice, high levels of Fra-2 give rise to profound inflammation with severe vascular and parenchymal remodelling, resulting in fibrosis, pulmonary hypertension and altered bronchial function.Birnhuber A, et al. (2019) Cell Signal. https://doi.org/10.1016/j.cellsig.2019.109408