Molecular Tuning of Actin Dynamics in Leukocyte Migration as Revealed by Immune-Related Actinopathies

This review focuses on how the generation and adaptation of diversified motility patterns in immune cells is sustained by actin cytoskeleton dynamics and related consequences of inborn errors of immunity (IEI). Kamnev A, et al. (2021) Front. Immunol. https://doi.org/10.3389/fimmu.2021.750537

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Therapeutic intervention with epigenetic modifications

‘Writers’ add marks, ‘Erasers’ read marks and ‘Readers’ detect marks. Scheme created for CelerisTx

Identification and selectivity profiling of small-molecule degraders via multi-omics approaches

Targeted protein degradation – A review on how proteomics and functional genomics can be integrated to identify and mechanistically understand degraders, their target selectivity as well as putative resistance mechanisms. Scholes NS, et al. (2021) Cell Chem. Biol. doi.org/10.1016/j.chembiol.2021.03.007

Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies

A review on actin dynamics at the T lymphocyte synapse in the context of dysfunctional actin regulators in immunodeficiency patients. Dupré L, et al. (2021) Front. Cell Dev. Biol. doi.org/10.3389/fcell.2021.665519

The nucleus acts as a ruler

Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This in turn activates signaling to the actomyosin cortex and enables cells to pass through restrictive pores in complex 3D environments. Lomakin A, et al. (2020) Science. doi: 10.1126/science.aba2894

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Polymerase δ deficiency

Identification of novel syndrome with replicative stress, neurodevelopmental abnormalities, and immunodeficiency. Conde CD and Petronczki ÖY, et al. (2019) J Clin Invest. doi: 10.1172/JCI128903

RhoG deficiency causes HLH

RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis. Kalinichenko A et al. (2021) Blood https://doi.org/10.1182/blood.2020008738

Culturing murine neurons

Stepwise procedure of neuronal dissection from murine hippocampus. Vanja Nagy/LBI-RUD Vienna 

Genotypic impact on sugar beet storability

An integrative comparative transcriptomic approach on six sugar beet varieties showing different amount of sucrose loss during storage revealed genotype-specific main driver genes and pathways characterizing storability. Study design according to overview figure. Madritsch S et al. (2020) Plant Mol Biol. https://doi.org/10.1007/s11103-020-01041-8

Fra-2 as a regulator of inflammation

Elevated expression of Fra-2 has been described in chronic lung diseases. In mice, high levels of Fra-2 give rise to profound inflammation with severe vascular and parenchymal remodelling, resulting in fibrosis, pulmonary hypertension and altered bronchial function.Birnhuber A, et al. (2019) Cell Signal. https://doi.org/10.1016/j.cellsig.2019.109408